CypA Regulates AIP4-Mediated M1 Ubiquitination of Influenza A Virus
نویسندگان
چکیده
منابع مشابه
Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication.
Influenza A virus RNA replication requires an intricate regulatory network involving viral and cellular proteins. In this study, we examined the roles of cellular ubiquitinating/deubiquitinating enzymes (DUBs). We observed that downregulation of a cellular deubiquitinating enzyme USP11 resulted in enhanced virus production, suggesting that USP11 could inhibit influenza virus replication. Conver...
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UNLABELLED Influenza A viruses (IAVs) rely on host factors to support their life cycle, as viral proteins hijack or interact with cellular proteins to execute their functions. Identification and understanding of these factors would increase our knowledge of the molecular mechanisms manipulated by the viruses. In this study, we searched for novel binding partners of the influenza A virus NS2 pro...
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Influenza A virus (IAV) RNA segments are individually packaged with viral nucleoprotein (NP) and RNA polymerases to form a viral ribonucleoprotein (vRNP) complex. We previously reported that NP is a monoubiquitinated protein which can be deubiquitinated by a cellular ubiquitin protease, USP11. In this study, we identified an E3 ubiquitin ligase, CNOT4 (Ccr4-Not transcription complex subunit 4),...
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ژورنال
عنوان ژورنال: Virologica Sinica
سال: 2018
ISSN: 1674-0769,1995-820X
DOI: 10.1007/s12250-018-0058-6